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However, derepression regarding ThPOK transcription into the DP thymocytes out of ThPOKCD4.Sil mice decorative mirrors term out-of endogenous Cd4 in DP thymocytes regarding wt mice. Like, the brand new SilThPOK prevents the brand new transcription away from Cd4 in the DP thymocytes out-of CD4ThPOK.Sil rats just like the suppression off endogenous ThPOK when you look at the DP thymocytes from wt mice. FACS data out-of TCR?, CD69, CD4, and you will CD8 term off (b) full thymocytes, gated thymocytes and you can (c) peripheral T-phone subsets of wt rats otherwise mutant outlines, once the shown. Statistical significance are determined for each and every indicated mutant range according to wt rats. FACS research out-of TCR?, CD69, CD4, and you will CD8 phrase out of complete thymocytes, gated thymocytes (c), and you may peripheral T-cellphone subsets (d) regarding wt rats otherwise mutant lines, as indicated.

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